Seeking help for drug addiction?

Addiction Advisor .co.uk is the leading online provider of free medical information about drug and alcohol addiction issues. You can receive independent, expert advice on addictions rehab and treatment by telephoning Addiction Advisor on 0845 370 0102

Understanding addiction mechanisms is the key to designing efficient therapy

The persistent nature of addiction is its most devastating feature. Understanding the mechanism underlying this phenomenon is the key for designing efficient therapy. Two separate studies published by Cell Press is the August 14 issue of the journal Neuron identify specific cocaine-induced changes in dopamine (DA) neurons that play a pivotal role in behaviours associated with drug addiction.

DA neurons in an area of the brain called the mesolimbic system play a major role in both reward and motivation and are a primary target for abused drugs. However, exactly how drug-induced synaptic changes in DA neurons relate to the development of addictive behaviors remains a critical unresolved issue.

Plastic changes in excitatory glutamate synapses on DA neurons in the ventral tegmental area (VTA) have been implicated in the process of addiction. Previous research has linked cocaine-induced synaptic strengthening in DA neurons in the VTA with activation of a subtype of glutamate receptors, called NMDA receptors (NMDAR) and with changes in the subunit composition of another type of glutamate receptor, AMPA receptors (AMPAR).

In one study, Dr. Larry S. Zweifel, and colleagues, from the Howard Hughes Medical Institute and the Department of Biochemistry at the University of Washington in Seattle, examined the link between glutamate signaling in DA neurons and long-term changes associated with drug exposure by selectively inactivating NMDAR signaling in DA neurons and testing two widely used models of addiction in mice.

Dr. Zweifel and colleagues observed that while the stimulatory effects of cocaine on motor activity were unaltered and behavioural sensitisation progressed normally, cue-evoked drug seeking and the enhancement of drug craving following withdrawal were significantly impaired in the mice lacking functional NMDAR in DA neurons. "Our findings support a role for NMDAR-dependent modulation of DA neurons in cue-induced relapse to drug seeking," says Dr. Zweifel.

In a separate study, Dr. Engblom and colleagues from German and Swiss research teams examined the relationship between glutamate signaling and drug-induced behaviour using mice lacking the GluR1, GluR2, or NR1 glutamate receptor subunits selectively in DA neurons.

The mice with perturbed NMDAR signaling or AMPAR plasticity in DA neurons
lacked cocaine-induced synaptic strengthening but exhibited normal basal and cocaine-induced DA release properties. However, the researches did observe two alterations in the persistence of drug-seeking behaviour. Interference with NMDAR signaling in DA neurons abolished cocaine relapse behaviour, and deletion of the GluR1 subunit in DA neurons resulted in a specific deficit in extinction of cocaine-induced reinforcement.

"Our findings link NMDAR signaling in DA neurons with relapse behaviour and provide a new rationale in the treatment of cocaine addiction. Specifically, the selective activation of the GluR1 subunit could potentially improve the outcome of any given exposure therapy," concludes Dr. Engblom.

Findings from both studies support the hypothesis that cocaine-evoked synaptic plasticity does not mediate concurrent short-term behaviour effects of the drug but may instead underlie long-term changes responsible for persistent drug-seeking behaviour.

References: Larry S. Zweifel et al., Role of NMDA Receptors in Dopamine Neurons for Plasticity and Addictive Behaviors, Neuron, Vol 59, 486-496, 14 August 2008

David Engblom et al., Glutamate Receptors on Dopamine Neurons Control the Persistence of Cocaine Seeking, Neuron, Vol 59, 497-508, 14 August 2008

Article originally published on 12/08/2008 by DryOutNow.com, the alcohol specific website for Addiction Advisor

Addictions Medical Research

• Brains reaction to self administered cocaine differs ...... read
• Understanding addiction mechanisms is the key to designing efficient therapy ...... read
• Nature or nurture, are you who your brain chemistry says you are? ...... read
• Statistics on Drug Misuse: England, 2008 released ...... read
• New evidence on addiction to medicines ...... read
• Risky drinking in over-55s becomes the focus of new research ...... read
• New drug and alcohol research presentations planned for annual meeting ...... read
• Coffee and cigarette consumption high among AA attendees ...... read
• The treatment of alcoholism: How recent research impacts on clinicians ...... read
• Dopamine shown to induce both desire and dread ...... read
• Pregnant substance users can deliver healthy babies with early treatment ...... read
• Minimum Drinking Age of 21 Saves Lives, Study Finds ...... read
• New Clinical Study for the Treatment of Opioid Dependence ...... read
• Broad Differences in Alcohol, Tobacco and Illegal Drug Use across Countries ...... read
• Binge drinking findings have implications for policy makers ...... read
• Kids connect alcohol odours with emotions ...... read
• Scientifically valid prevention programmes cut rates of juvenile delinquency ...... read
• United Nations Drugs Day ...... read
• Substance abuse problems could be addressed at a local level ...... read
• BMA backs alcohol action plan ...... read